全文获取类型
收费全文 | 3903057篇 |
免费 | 335228篇 |
国内免费 | 14607篇 |
专业分类
耳鼻咽喉 | 55167篇 |
儿科学 | 125479篇 |
妇产科学 | 103260篇 |
基础医学 | 603832篇 |
口腔科学 | 108017篇 |
临床医学 | 351354篇 |
内科学 | 700789篇 |
皮肤病学 | 98321篇 |
神经病学 | 330658篇 |
特种医学 | 158288篇 |
外国民族医学 | 640篇 |
外科学 | 608866篇 |
综合类 | 118107篇 |
现状与发展 | 24篇 |
一般理论 | 2411篇 |
预防医学 | 325533篇 |
眼科学 | 90775篇 |
药学 | 273824篇 |
19篇 | |
中国医学 | 10362篇 |
肿瘤学 | 187166篇 |
出版年
2021年 | 49796篇 |
2020年 | 35340篇 |
2019年 | 58416篇 |
2018年 | 72615篇 |
2017年 | 55099篇 |
2016年 | 60990篇 |
2015年 | 74627篇 |
2014年 | 109003篇 |
2013年 | 174217篇 |
2012年 | 106810篇 |
2011年 | 109521篇 |
2010年 | 120981篇 |
2009年 | 124103篇 |
2008年 | 96727篇 |
2007年 | 102291篇 |
2006年 | 111623篇 |
2005年 | 107415篇 |
2004年 | 108759篇 |
2003年 | 99189篇 |
2002年 | 88251篇 |
2001年 | 137568篇 |
2000年 | 132033篇 |
1999年 | 123025篇 |
1998年 | 63324篇 |
1997年 | 60121篇 |
1996年 | 58177篇 |
1995年 | 59175篇 |
1994年 | 53318篇 |
1993年 | 49643篇 |
1992年 | 91288篇 |
1991年 | 87595篇 |
1990年 | 83775篇 |
1989年 | 81444篇 |
1988年 | 75627篇 |
1987年 | 73973篇 |
1986年 | 70436篇 |
1985年 | 69554篇 |
1984年 | 59754篇 |
1983年 | 53330篇 |
1982年 | 45383篇 |
1981年 | 42240篇 |
1980年 | 39802篇 |
1979年 | 51027篇 |
1978年 | 42393篇 |
1977年 | 37671篇 |
1976年 | 34938篇 |
1975年 | 34451篇 |
1974年 | 37417篇 |
1973年 | 35886篇 |
1972年 | 33787篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
101.
Koji Sasaki Tapan Kadia Kebede Begna Courtney D. DiNardo Gautam Borthakur Nicholas J. Short Nitin Jain Naval Daver Elias Jabbour Guillermo Garcia-Manero Guillermo Montalban Bravo Lucia Masarova Sherry Pierce Marina Konopleva Farhad Ravandi Ayalew Tefferi Hagop Kantarjian 《American journal of hematology》2022,97(1):68-78
The progress with intensive chemotherapy and supportive care measures has improved survival in patients with newly diagnosed acute myeloid leukemia (AML). Given the recent development of effective low intensity therapies, an optimal decision on the therapy intensity may improve survival through the avoidance of early mortality. We reviewed the outcome of 3728 patients with newly diagnosed AML who received intensive chemotherapy between August 1980 and May 2020. Intensive chemotherapy was defined as a cumulative cytarabine dose ≥ 700 mg/m2 during induction therapy. We divided the whole cohort into a training and validation group at a 3:1 ratio. The population was divided into a training (2790 patients) and a validation cohort (938 patients). The median age was 55 years (range, 15-99). Among them, 442 patients (12%) had core-binding factor AML. Binary logistic regression identified older age, worse performance status, hyperbilirubinemia, elevated creatinine, hyperuricemia, cytogenetic abnormalities other than CBF and -Y, and pneumonia as adverse prognostic factors for an early 4-week mortality. This risk classification for early mortality was verified in the validation cohort of patients. In the validation cohort of more recently treated patients from 2000 to 2017, the 4-week mortality rates with intensive chemotherapy were 2%, 14%, and 50% in the low-, high-, and very high-risk group, respectively. The mortality rates with low intensity therapies were 3%, 9%, and 20%, respectively. The risk classification guides treatment intensity by the assessment of age, frailty, organ dysfunction, cytogenetic abnormality, and infection to avoid early mortality. 相似文献
102.
Techniques in Coloproctology - 相似文献
103.
104.
Roby Naym U. Packham Tara L. MacDermid Joy C. Carlesso Lisa C. 《Clinical rheumatology》2022,41(10):3159-3168
Clinical Rheumatology - Central sensitization (CS) is a known contributor to chronic pain in people with knee osteoarthritis (KOA) and is commonly measured by psychophysical testing or... 相似文献
105.
Vilar-Compte Mireya Gaitán-Rossi Pablo Félix-Beltrán Lucía Bustamante Arturo V. 《Journal of immigrant and minority health / Center for Minority Public Health》2022,24(1):65-77
Journal of Immigrant and Minority Health - COVID-19 has disproportionally affected underrepresented minorities (URM) and low-income immigrants in the United States. The aim of the study is to... 相似文献
106.
107.
Delirium is one of the most commonly occurring postoperative complications in older adults. It occurs due to the vulnerability of cerebral functioning to pathophysiological stressors. Identification of those at increased risk of developing delirium early in the surgical pathway provides an opportunity for modification of predisposing and precipitating risk factors and effective shared decision-making. No single delirium prediction tool is used widely in surgical settings. Multi-component interventions to prevent delirium involve structured risk factor modification supported by geriatrician input; these are clinically efficacious and cost effective. Barriers to the widespread implementation of such complex interventions exist, resulting in an ‘implementation gap’. There is a lack of evidence for pharmacological prophylaxis for the prevention of delirium. Current evidence suggests that avoidance of peri-operative benzodiazepines, careful titration of anaesthetic depth guided by processed electroencephalogram monitoring and treatment of pain are the most effective strategies to minimise the risk of delirium. Addressing postoperative delirium requires a collaborative, whole pathway approach, beginning with the early identification of those patients who are at risk. The research agenda should continue to examine the potential for pharmacological prophylaxis to prevent delirium while also addressing how successful models of delirium prevention can be translated from one setting to another, underpinned by implementation science methodology. 相似文献
108.
Die Anaesthesiologie - Als Meralgia paraesthetica (MP) bezeichnet man eine zu den neurologischen Engpasssyndromen zählende Schädigung des aus dem Plexus lumbalis entspringenden sensiblen... 相似文献
109.
Cody M. Lebeck Lee MD Ioannis A. Ziogas MD Rajiv Agarwal MD Sophoclis P. Alexopoulos MD Kristen K. Ciombor MD Lea K. Matsuoka MD Daniel B. Brown MD Cathy Eng MD 《Cancer》2022,128(12):2243-2257
The 5-year overall survival rate of a patient with unresectable metastatic colorectal cancer is poor at approximately 14%. Similarly, historical data on liver transplantation (LT) in those with colorectal liver metastases (CRLM) showed poor outcomes, with 5-year survival rates between 12% and 21%. More recently, limited data have shown improved outcomes in select patients with 5-year overall survival rates of approximately 60%. Despite these reported survival improvements, there is no significant improvement in disease-free survival. Given the uncertain benefit with this therapeutic approach and a renewed investigational interest, we aimed to conduct a contemporary systematic review on LT for CRLM. A systematic review of the literature was performed according to the preferred reporting items for systematic reviews and meta-analysis statement. English articles reporting on data regarding LT for CRLM were identified through the MEDLINE (via PubMed), Cochrane Library, and ClinicalTrials.gov databases (last search date: December 16th, 2021) by 2 researchers independently. A total of 58 studies (45 published and 13 ongoing) were included. Although early retrospective studies suggest the possibility that some carefully selected patients may benefit from LT, there is minimal prospective data on the topic and LT remains exploratory in the setting of CRLM. Additionally, several other challenges, such as the limited availability of deceased donor organs and defining appropriate selection criteria, remain when considering the implementation of LT for these patients. Further evidence from ongoing prospective trials is needed to determine if and to what extent there is a role for LT in patients with surgically unresectable CRLM. 相似文献
110.
Greer Hunter R. Miller Kristen Samay Sadaf Nellan Anandani Green Adam L. 《Journal of neuro-oncology》2022,159(2):301-308
Journal of Neuro-Oncology - The role of white blood cells (WBC) in the pediatric central nervous system (CNS) tumor microenvironment is incompletely defined. We hypothesized that the WBC profile in... 相似文献